Wouldn’t it be wonderful if the insulin injected was able to decide when it was needed? What if it were essentially able to turn itself on and off? Well, researchers are looking at just that ability. A team of researchers at the University of Utah and Massachusetts Institute of Technology are working on a new form of insulin that is glucose responsive. This would allow insulin to be self-regulating. Researchers are trying a new approach using a chemical group known as PBA. PBA would bind to the glucose and activate the insulin whenever it is needed. In mouse models Ins-PBA-F works as quickly as insulin does in a healthy mouse. Researchers hope to reach clinical trials in two to five years.